theJONESlab

Cancer metabolism & immunology

Goodman Cancer Research Centre | Department of Physiology | McGill University

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Publications

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Rabinovitch, R.C., Samborska, B., Faubert, B., Ma, E.H., Gravel, S.P., Andrzejewski, S., Raissi, T.C., Pause, A., St-Pierre, J., Jones, R.G. (2017). AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species. Cell Rep., 21(1):1-9.
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Ma, E. H., Bantug, G., Griss, T., Condotta, S., Johnson, R. M., Samborska, B., … Jones, R. G. (2017). Serine Is an Essential Metabolite for Effector T Cell Expansion. Cell Metabolism, 25(2), 345–357.
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Izreig, S., Samborska, B., Johnson, R. M., Sergushichev, A., Ma, E. H., Lussier, C., … Jones, R. G. (2016). The miR-17~92 microRNA Cluster Is a Global Regulator of Tumor Metabolism. Cell Reports, 16(7), 1915–1928.
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Ma, E. H., Jones, R. G. (2016). CELL GROWTH. (TORC)ing up purine biosynthesis. Science, 351(6274), 670–1. https://doi.org/10.1126/science.aaf1929
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Blagih, J., Coulombe, F., Vincent, E. E., Dupuy, F., Galicia-Vázquez, G., Yurchenko, E., … Jones, R. G. (2015). The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo. Immunity, 42(1), 41–54.
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Dupuy, F., Tabariès, S., Andrzejewski, S., Dong, Z., Blagih, J., Annis, M. G., … Siegel, P. M. (2015). PDK1-dependent metabolic reprogramming dictates metastatic potential in breast cancer. Cell Metabolism, 22(4), 577–589.
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Faubert, B., Vincent, E. E., Poffenberger, M. C., & Jones, R. G. (2015). The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator. Cancer Letters, 356(2), 165–170.
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Griss, T., Vincent, E. E., Egnatchik, R., Chen, J., Ma, E. H., Faubert, B., … Jones, R. G. (2015). Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis. PLoS Biology, 13(12), 1–23.
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Vincent, E. E., Coelho, P. P., Blagih, J., Griss, T., Viollet, B., & Jones, R. G. (2015). Differential effects of AMPK agonists on cell growth and metabolism. Oncogene, 34(28), 3627–39.
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Vincent, E. E., Sergushichev, A., Griss, T., Gingras, M. C., Samborska, B., Ntimbane, T., … Jones, R. G. (2015). Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth. Molecular Cell, 60(2), 195–207.
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Faubert, B., Vincent, E. E., Griss, T., Samborska, B., Izreig, S., Svensson, R. U., … Jones, R. G. (2014). Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1alpha. Proc Natl Acad Sci U S A, 111(7), 2554–59.
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Poffenberger, M. C., & Jones, R. G. (2014). Amino acids fuel T cell-mediated inflammation. Immunity, 40(5), 635–637.
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Dupuy, F., Griss, T., Blagih, J., Bridon, G., Avizonis, D., Ling, C., … Jones, R. G. (2013). LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer. Cancer & Metabolism, 1(1), 18.
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Pearce, EL, Poffenberger, MC, Chang, C, Jones, RG. (2013). Fueling Immunity: Insights into Metabolism and Lymphocyte Function. Science, 342(6155), 1242454.
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Faubert, B., Boily, G., Izreig, S., Griss, T., Samborska, B., Dong, Z., Dupuy, F., Chambers, C., Fuerth, B., Viollet, B., Mamer, OA., Avizonis, D., Deberardinis, RJ., Siegel, PM., Jones, RG (2013). AMPK is a negative regulator of the Warburg Effect, and suppresses tumour growth in vivo. Cell Metabolism. (17)1:113-24.
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Blagih, J., Krawczyk, C., Jones, RG. (2012) LKB1 and AMPK: central regulators of lymphocyte metabolism and function. Immunol. Rev. (249)1:59-71.
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MacIver, N.J., Blagih, J., Saucillo, D.C., Tonelli, L., Griss, T., Rathmell, J.C., Jones, R.G. (2011) The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J Immunol. 187(8):4187-98.
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